This research project empirically investigates potential relationships of specific work conditions associated with digitalization as well as short- and medium-term biomedical stress reactions, and long-term consequences for the health of employees. Based on a conceptual framework a systematic review and two applied studies in the workplace will be conducted. These studies aim at providing empirical evidence on the health-related impact of three specific work characteristics, namely work intensity / amount of information, interruptions and distractions through digital technologies and media, as well as multi-tasking. Moreover, we are interested in the amplifying effect of task characteristics and we will examine stress and health consequences using established methods within the field of occupational medicine, work psychology, and biological psychology. The findings of this research project shall provide novel insights into potentially negative but also positive health implications of using digital technologies in the workplace.